STRING 10 
  RIPK1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with d [...] (671 aa)
(Homo sapiens)
Predicted Functional Partners:
FADD
Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)
     0.999
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
     0.999
TRAF2
TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a centra [...] (501 aa)
     0.999
CASP8
caspase 8, apoptosis-related cysteine peptidase (538 aa)
     0.999
RIPK3
receptor-interacting serine-threonine kinase 3; Essential for programmed necrosis in response t [...] (518 aa)
    0.999
TRADD
TNFRSF1A-associated via death domain; The nuclear form acts as a tumor suppressor by preventing [...] (312 aa)
     0.999
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)
      0.999
UBC
ubiquitin C (685 aa)
      0.999
BIRC2
baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases [...] (618 aa)
     0.998
TRAF1
TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B [...] (416 aa)
     0.997
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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