RIPK1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with d [...] (671 aa)
(Homo sapiens)
Predicted Functional Partners:
Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a centra [...] (501 aa)
caspase 8, apoptosis-related cysteine peptidase (538 aa)
receptor-interacting serine-threonine kinase 3; Essential for programmed necrosis in response t [...] (518 aa)
TNFRSF1A-associated via death domain; The nuclear form acts as a tumor suppressor by preventing [...] (312 aa)
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)
ubiquitin C (685 aa)
baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases [...] (618 aa)
TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B [...] (416 aa)
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