RIPK1 protein (Homo sapiens) - STRING network view

STRING 9.05

RIPK1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...] (671 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CASP8	caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation casca [...] (538 aa)	•	•	•		0.999
	TRAF2	TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)	•	•	•		0.999
	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)	•	•	•	•	0.999
	FADD	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)	•	•	•	•	0.999
	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)	•	•	•		0.999
	RIPK3	receptor-interacting serine-threonine kinase 3; Promotes apoptosis (518 aa)	•	•	•	•	0.999
	BIRC2	baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with [...] (618 aa)	•	•	•		0.999
	UBC	ubiquitin C (685 aa)	•		•		0.999
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain; Apoptotic adaptor molecule specifi [...] (199 aa)	•	•	•		0.998
	TNF	tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)	•		•		0.998

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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