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ENSG00000234012 - Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1); Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1/CHK1 and CHEK2/CHK2/CDS1 kinases, and stabilizatio [...]
MDC1 - mediator of DNA-damage checkpoint 1
NFBD1 - Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)