ANGPT1 protein (Homo sapiens) - STRING network view

STRING 9.05

ANGPT1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	ANGPT1	angiopoietin 1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (498 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TEK	TEK tyrosine kinase, endothelial; This protein is a protein tyrosine-kinase transmembrane recep [...] (1124 aa)	•	•	•		0.999
	VEGFA	vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and [...] (412 aa)			•		0.966
	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a recep [...] (1049 aa)	•	•	•		0.964
	ANGPT2	angiopoietin 2; Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counter [...] (496 aa)	•	•	•	•	0.961
	FN1	fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)		•	•		0.939
	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); In addit [...] (660 aa)		•	•		0.937
	PLG	plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a [...] (810 aa)		•	•		0.927
	PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide; Phosphorylates PtdIns, PtdIns4P and Ptd [...] (1070 aa)		•	•		0.921
	PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and Pt [...] (1068 aa)		•	•		0.919
	ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor (485 aa)		•	•		0.917

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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