DCC protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	DCC	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor); Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (1447 aa)
		(Homo sapiens)
Predicted Functional Partners:
	NTN1	Netrin-1 precursor; Netrins control guidance of CNS commissural axons and peripheral motor axon [...] (604 aa)	•	•	•	0.999
	PTK2	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2); Non-rec [...] (1052 aa)	•		•	0.973
	UNC5B	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for [...] (945 aa)		•	•	0.959
	CASP3	Caspase-3 precursor (EC 3.4.22.56) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) [...] (277 aa)	•	•	•	0.941
	UNC5A	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1); Receptor for netrin requir [...] (842 aa)		•	•	0.933
	NCK1	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha); Adapter p [...] (377 aa)	•	•	•	0.924
	UNC5D	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4); Receptor for netrin. May b [...] (953 aa)		•	•	0.909
	MAZ	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1) (ZF87) [...] (497 aa)	•		•	0.905
	MAPK3	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ER [...] (379 aa)	•		•	0.871
	RHOA	Transforming protein RhoA precursor (H12); Regulates a signal transduction pathway linking plas [...] (197 aa)		•	•	0.869

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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