NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (ADRAB-F) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48); Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12- oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity) (217 aa)