Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46); Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) (427 aa)

Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarco [...] (331 aa)

C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP [...] (711 aa)

Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) [...] (399 aa)

Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP respo [...] (505 aa)

Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-d [...] (239 aa)

Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13); Acts [...] (393 aa)

Insulin receptor substrate 1 (IRS-1); May mediate the control of various cellular processes by [...] (1242 aa)

C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP [...] (1342 aa)

Dual specificity protein phosphatase 10 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein [...] (482 aa)

Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface [...] (277 aa)