node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGO3 | LRCH3 | ENSP00000362287 | ENSP00000399751 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity bu [...] | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | 0.557 |
AGO3 | ZNF791 | ENSP00000362287 | ENSP00000342974 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity bu [...] | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.638 |
GOSR1 | LRCH3 | ENSP00000225724 | ENSP00000399751 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | 0.778 |
GOSR1 | ZNF791 | ENSP00000225724 | ENSP00000342974 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.448 |
LRCH3 | AGO3 | ENSP00000399751 | ENSP00000362287 | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity bu [...] | 0.557 |
LRCH3 | GOSR1 | ENSP00000399751 | ENSP00000225724 | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.778 |
LRCH3 | ZNF791 | ENSP00000399751 | ENSP00000342974 | DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.466 |
NKAP | ZNF791 | ENSP00000360464 | ENSP00000342974 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter; Belongs to the NKAP family. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.538 |
OR4F21 | ZNF487 | ENSP00000318878 | ENSP00000498490 | Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Putative zinc finger protein 487; May be involved in transcriptional regulation. | 0.581 |
OR4F21 | ZNF791 | ENSP00000318878 | ENSP00000342974 | Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.444 |
TMCO6 | ZNF791 | ENSP00000252100 | ENSP00000342974 | Transmembrane and coiled-coil domains 6. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.441 |
TRIM28 | ZNF766 | ENSP00000253024 | ENSP00000409652 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.555 |
TRIM28 | ZNF791 | ENSP00000253024 | ENSP00000342974 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.586 |
ZBTB25 | ZNF766 | ENSP00000476746 | ENSP00000409652 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.424 |
ZBTB25 | ZNF791 | ENSP00000476746 | ENSP00000342974 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.445 |
ZNF487 | OR4F21 | ENSP00000498490 | ENSP00000318878 | Putative zinc finger protein 487; May be involved in transcriptional regulation. | Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.581 |
ZNF487 | ZNF791 | ENSP00000498490 | ENSP00000342974 | Putative zinc finger protein 487; May be involved in transcriptional regulation. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.431 |
ZNF766 | TRIM28 | ENSP00000409652 | ENSP00000253024 | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.555 |
ZNF766 | ZBTB25 | ENSP00000409652 | ENSP00000476746 | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation. | 0.424 |
ZNF766 | ZNF791 | ENSP00000409652 | ENSP00000342974 | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 791; May be involved in transcriptional regulation. | 0.798 |