Lef1 protein (Mus musculus) - STRING interaction network

Lef1 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Lef1	lymphoid enhancer binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (397 aa)
		(Mus musculus)
Predicted Functional Partners:
	Ctnnb1	catenin (cadherin associated protein), beta 1; Involved in the regulation of cell adhesion and [...] (781 aa)	•	•	•	0.999
	Wnt3a	wingless-related MMTV integration site 3A; Ligand for members of the frizzled family of seven t [...] (352 aa)			•	0.978
	Cdh1	cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interac [...] (884 aa)			•	0.976
	Alx4	aristaless 4; Transcription factor involved in skull and limb development (399 aa)	•		•	0.972
	Jup	junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are ar [...] (745 aa)	•	•	•	0.952
	Bmp4	bone morphogenetic protein 4; Induces cartilage and bone formation (419 aa)			•	0.949
	Msx1	homeo box, msh-like 1; Acts as a transcriptional repressor. May play a role in limb-pattern for [...] (303 aa)			•	0.947
	Pax9	paired box gene 9; Transcription factor required for normal development of thymus, parathyroid [...] (342 aa)			•	0.916
	Rag2	recombination activating gene 2; During lymphocyte development, the genes encoding immunoglobul [...] (527 aa)		•	•	0.904
	Runx2	runt related transcription factor 2; Transcription factor involved in osteoblastic differentiat [...] (509 aa)	•		•	0.900

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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