Runx1 protein (Mus musculus) - STRING network view

STRING 9.05

Runx1 protein (Mus musculus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	Runx1	runt related transcription factor 1 Gene; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter [...] (465 aa)
		(Mus musculus)
Predicted Functional Partners:
	Cbfb	core binding factor beta Gene; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhan [...] (187 aa)	•	•	•	0.994
	Sin3a	transcriptional regulator, SIN3A (yeast) Gene; Acts as a transcriptional repressor. Interacts w [...] (1282 aa)	•		•	0.982
	Tal1	T-cell acute lymphocytic leukemia 1 Gene; Implicated in the genesis of hemopoietic malignancies [...] (329 aa)	•		•	0.961
	Hdac1	histone deacetylase 1 Gene; Responsible for the deacetylation of lysine residues on the N-termi [...] (482 aa)	•	•	•	0.943
	Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related) Gene; Transcription [...] (604 aa)	•	•	•	0.928
	Hdac2	histone deacetylase 2 Gene; Responsible for the deacetylation of lysine residues on the N-termi [...] (488 aa)	•	•	•	0.927
	Cdk6	cyclin-dependent kinase 6 Gene; Probably involved in the control of the cell cycle. Interacts w [...] (326 aa)	•		•	0.924
	Prmt1	protein arginine N-methyltransferase 1 Gene; Methylates (mono and asymmetric dimethylation) the [...] (371 aa)	•		•	0.920
	Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha Gene; C/EBP is a DNA-binding protein that recogni [...] (359 aa)		•	•	0.906
	Ets1	E26 avian leukemia oncogene 1, 5' domain Gene; Transcription factor (440 aa)	•		•	0.900

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: low (7%)

Permalink