CD40LG protein (Homo sapiens) - STRING network view

STRING 9.05

CD40LG protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	CD40LG	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching (261 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CD40	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG (277 aa)	•	•	•	0.999
	TRAF1	TNF receptor-associated factor 1; Adapter protein and signal transducer that links members of t [...] (416 aa)		•	•	0.987
	CD4	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regul [...] (458 aa)			•	0.968
	CD86	CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte prolife [...] (329 aa)			•	0.964
	IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker) (399 aa)	•		•	0.960
	TRAF3	TNF receptor-associated factor 3; Adapter protein and signal transducer that links members of t [...] (568 aa)		•	•	0.948
	TRAF6	TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)		•	•	0.948
	CD83	CD83 molecule; May play a significant role in antigen presentation or the cellular interactions [...] (205 aa)			•	0.946
	ICAM1	intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein [...] (532 aa)			•	0.946
	RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic trans [...] (551 aa)		•	•	0.938

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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