node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bhlha15 | Zfand3 | ENSMUSP00000055493 | ENSMUSP00000063158 | Class A basic helix-loop-helix protein 15; Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression [...] | AN1-type zinc finger protein 3. | 0.443 |
Bhlha15 | Zfp512b | ENSMUSP00000055493 | ENSMUSP00000104417 | Class A basic helix-loop-helix protein 15; Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression [...] | Zinc finger protein 512B. | 0.416 |
C2cd4a | Zfand3 | ENSMUSP00000058286 | ENSMUSP00000063158 | C2 calcium-dependent domain-containing 4A. | AN1-type zinc finger protein 3. | 0.446 |
Kcnk16 | Zfand3 | ENSMUSP00000024155 | ENSMUSP00000063158 | Potassium channel, subfamily K, member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | AN1-type zinc finger protein 3. | 0.459 |
Rab22a | Rabep1 | ENSMUSP00000029024 | ENSMUSP00000075619 | Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF- mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity). Belongs to the small GTPase superfamily. Rab family. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family. | 0.698 |
Rab22a | Zfand3 | ENSMUSP00000029024 | ENSMUSP00000063158 | Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF- mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity). Belongs to the small GTPase superfamily. Rab family. | AN1-type zinc finger protein 3. | 0.494 |
Rab5c | Rabep1 | ENSMUSP00000019317 | ENSMUSP00000075619 | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family. | 0.776 |
Rab5c | Zfand3 | ENSMUSP00000019317 | ENSMUSP00000063158 | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | AN1-type zinc finger protein 3. | 0.476 |
Rabep1 | Rab22a | ENSMUSP00000075619 | ENSMUSP00000029024 | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family. | Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF- mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity). Belongs to the small GTPase superfamily. Rab family. | 0.698 |
Rabep1 | Rab5c | ENSMUSP00000075619 | ENSMUSP00000019317 | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family. | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.776 |
Rabep1 | Zfand3 | ENSMUSP00000075619 | ENSMUSP00000063158 | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family. | AN1-type zinc finger protein 3. | 0.510 |
Rabep2 | Zfand3 | ENSMUSP00000102015 | ENSMUSP00000063158 | Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Belongs to the rabaptin family. | AN1-type zinc finger protein 3. | 0.502 |
Usp33 | Zfand3 | ENSMUSP00000142708 | ENSMUSP00000063158 | Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] | AN1-type zinc finger protein 3. | 0.587 |
Zfand3 | Bhlha15 | ENSMUSP00000063158 | ENSMUSP00000055493 | AN1-type zinc finger protein 3. | Class A basic helix-loop-helix protein 15; Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression [...] | 0.443 |
Zfand3 | C2cd4a | ENSMUSP00000063158 | ENSMUSP00000058286 | AN1-type zinc finger protein 3. | C2 calcium-dependent domain-containing 4A. | 0.446 |
Zfand3 | Kcnk16 | ENSMUSP00000063158 | ENSMUSP00000024155 | AN1-type zinc finger protein 3. | Potassium channel, subfamily K, member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.459 |
Zfand3 | Rab22a | ENSMUSP00000063158 | ENSMUSP00000029024 | AN1-type zinc finger protein 3. | Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF- mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity). Belongs to the small GTPase superfamily. Rab family. | 0.494 |
Zfand3 | Rab5c | ENSMUSP00000063158 | ENSMUSP00000019317 | AN1-type zinc finger protein 3. | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. | 0.476 |
Zfand3 | Rabep1 | ENSMUSP00000063158 | ENSMUSP00000075619 | AN1-type zinc finger protein 3. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family. | 0.510 |
Zfand3 | Rabep2 | ENSMUSP00000063158 | ENSMUSP00000102015 | AN1-type zinc finger protein 3. | Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Belongs to the rabaptin family. | 0.502 |