STRINGSTRING
Ifi30 Ifi30 Wdr90 Wdr90 Ccdc15 Ccdc15 Sh2d4a Sh2d4a RGD1309139 RGD1309139 Ccpg1os Ccpg1os Pacrgl Pacrgl Efhb Efhb Cfap126 Cfap126 Spag8 Spag8 RGD1560242 RGD1560242
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Ifi30Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity); Belongs to the GILT family. (248 aa)    
Predicted Functional Partners:
Wdr90
WD repeat domain 90.
    
 
 0.770
Ccdc15
Coiled-coil domain-containing 15.
      
 0.580
Sh2d4a
SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T- cell development and function (By similarity).
   
  
 0.540
RGD1309139
Similar to CG5435-PA (Predicted).
   
   0.534
Ccpg1os
Cell cycle progression 1, opposite strand.
   
   0.531
Pacrgl
Similar to RIKEN cDNA 4933428G09 (Predicted), isoform CRA_b.
    
   0.528
Efhb
EF hand domain family, member B.
    
   0.528
Cfap126
Similar to RIKEN cDNA 1700009P17 (Predicted), isoform CRA_a.
    
   0.528
Spag8
Sperm-associated antigen 8.
    
   0.528
RGD1560242
Similar to RIKEN cDNA 1700028P14 (Predicted).
    
   0.528
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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