STRINGSTRING
Trp53i11 Trp53i11 Txnl1 Txnl1 Trp53 Trp53 Trp53i13 Trp53i13 Prrx2 Prrx2 Yjefn3 Yjefn3 Efcab10 Efcab10 Trp53rkb Trp53rkb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
Trp53i11Tumor protein p53-inducible protein 11. (189 aa)    
Predicted Functional Partners:
Txnl1
Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV.
      
 0.595
Trp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
   
 
 0.527
Trp53i13
Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity).
      
 0.465
Prrx2
Paired mesoderm homeobox protein 2; Belongs to the paired homeobox family.
      
 0.433
Yjefn3
YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis.
      
 0.432
Efcab10
EF-hand calcium-binding domain-containing protein 10.
      
 0.405
Trp53rkb
EKC/KEOPS complex subunit Tp53rk; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may t [...]
      
 0.402
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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