node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Chd3 | Chd4 | ENSRNOP00000053890 | ENSRNOP00000052823 | Chromodomain helicase DNA-binding protein 3. | Chromodomain helicase DNA-binding protein 4. | 0.993 |
Chd3 | Dnmt1 | ENSRNOP00000053890 | ENSRNOP00000063831 | Chromodomain helicase DNA-binding protein 3. | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | 0.544 |
Chd3 | Hdac1 | ENSRNOP00000053890 | ENSRNOP00000012854 | Chromodomain helicase DNA-binding protein 3. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.998 |
Chd3 | Hdac2 | ENSRNOP00000053890 | ENSRNOP00000000742 | Chromodomain helicase DNA-binding protein 3. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.998 |
Chd3 | Mecp2 | ENSRNOP00000053890 | ENSRNOP00000069913 | Chromodomain helicase DNA-binding protein 3. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). | 0.466 |
Chd3 | Rbbp4 | ENSRNOP00000053890 | ENSRNOP00000036568 | Chromodomain helicase DNA-binding protein 3. | RB-binding protein 4, chromatin-remodeling factor. | 0.995 |
Chd3 | Sap30 | ENSRNOP00000053890 | ENSRNOP00000017652 | Chromodomain helicase DNA-binding protein 3. | Sin3 associated polypeptide. | 0.652 |
Chd3 | Sin3a | ENSRNOP00000053890 | ENSRNOP00000072640 | Chromodomain helicase DNA-binding protein 3. | SIN3 transcription regulator family member A. | 0.537 |
Chd4 | Chd3 | ENSRNOP00000052823 | ENSRNOP00000053890 | Chromodomain helicase DNA-binding protein 4. | Chromodomain helicase DNA-binding protein 3. | 0.993 |
Chd4 | Dnmt1 | ENSRNOP00000052823 | ENSRNOP00000063831 | Chromodomain helicase DNA-binding protein 4. | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | 0.515 |
Chd4 | Hdac1 | ENSRNOP00000052823 | ENSRNOP00000012854 | Chromodomain helicase DNA-binding protein 4. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.999 |
Chd4 | Hdac2 | ENSRNOP00000052823 | ENSRNOP00000000742 | Chromodomain helicase DNA-binding protein 4. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.999 |
Chd4 | Mecp2 | ENSRNOP00000052823 | ENSRNOP00000069913 | Chromodomain helicase DNA-binding protein 4. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). | 0.549 |
Chd4 | Ncor1 | ENSRNOP00000052823 | ENSRNOP00000072175 | Chromodomain helicase DNA-binding protein 4. | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB [...] | 0.595 |
Chd4 | Rbbp4 | ENSRNOP00000052823 | ENSRNOP00000036568 | Chromodomain helicase DNA-binding protein 4. | RB-binding protein 4, chromatin-remodeling factor. | 0.988 |
Chd4 | Sap30 | ENSRNOP00000052823 | ENSRNOP00000017652 | Chromodomain helicase DNA-binding protein 4. | Sin3 associated polypeptide. | 0.774 |
Chd4 | Sin3a | ENSRNOP00000052823 | ENSRNOP00000072640 | Chromodomain helicase DNA-binding protein 4. | SIN3 transcription regulator family member A. | 0.755 |
Chd4 | Yy1 | ENSRNOP00000052823 | ENSRNOP00000005743 | Chromodomain helicase DNA-binding protein 4. | Transcription factor YY1. | 0.533 |
Dnmt1 | Chd3 | ENSRNOP00000063831 | ENSRNOP00000053890 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | Chromodomain helicase DNA-binding protein 3. | 0.544 |
Dnmt1 | Chd4 | ENSRNOP00000063831 | ENSRNOP00000052823 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | Chromodomain helicase DNA-binding protein 4. | 0.515 |