Sfrp1 protein (Mus musculus) - STRING interaction network

Sfrp1 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Sfrp1	secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By simila [...] (314 aa)
		(Mus musculus)
Predicted Functional Partners:
	Wnt3a	wingless-related MMTV integration site 3A; Ligand for members of the frizzled family of seven t [...] (352 aa)	•	•	0.990
	Wnt5a	wingless-related MMTV integration site 5A; Ligand for members of the frizzled family of seven t [...] (380 aa)	•	•	0.985
	Wnt7b	wingless-related MMTV integration site 7B; Ligand for members of the frizzled family of seven t [...] (471 aa)	•	•	0.974
	Wnt1	wingless-related MMTV integration site 1; Ligand for members of the frizzled family of seven tr [...] (370 aa)	•	•	0.967
	Wnt2b	wingless related MMTV integration site 2b; Ligand for members of the frizzled family of seven t [...] (389 aa)	•	•	0.946
	Wnt6	wingless-related MMTV integration site 6; Ligand for members of the frizzled family of seven tr [...] (364 aa)	•	•	0.939
	Wnt10b	wingless related MMTV integration site 10b; Ligand for members of the frizzled family of seven [...] (389 aa)	•	•	0.934
	Ctnnb1	catenin (cadherin associated protein), beta 1; Involved in the regulation of cell adhesion and [...] (781 aa)		•	0.914
	Wnt2	wingless-related MMTV integration site 2; Ligand for members of the frizzled family of seven tr [...] (360 aa)	•	•	0.912
	Wnt9a	wingless-type MMTV integration site 9A; Ligand for members of the frizzled family of seven tran [...] (365 aa)	•	•	0.905

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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