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  CTLA4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CTLA4
Cytotoxic T-lymphocyte protein 4 precursor (Cytotoxic T-lymphocyte- associated antigen 4) (CTLA-4) (CD152 antigen); Possibly involved in T-cell activation. Binds to B7-1 (CD80) and B7-2 (CD86) (223 aa)
(Homo sapiens)
Predicted Functional Partners:
CD80
T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-recept [...] (288 aa)
    ••• 0.999
CD86
T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-recept [...] (329 aa)
    ••• 0.999
PTPN11
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2 [...] (593 aa)
    ••• 0.997
AP2M1
AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50 [...] (435 aa)
    • • 0.994
LCK
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific pr [...] (539 aa)
    ••• 0.993
FOXP3
Forkhead box protein P3 (Scurfin); Probable transcription factor. Plays a critical role in the [...] (441 aa)
     •• 0.993
IL10
Interleukin-10 precursor (IL-10) (Cytokine synthesis inhibitory factor) (CSIF); Inhibits the sy [...] (178 aa)
      • 0.991
IL2
Interleukin-2 precursor (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin); Produced by T-cells [...] (153 aa)
      • 0.991
FYN
Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK); I [...] (537 aa)
    ••• 0.988
NFATC2
Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pr [...] (925 aa)
     •• 0.987
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth
       
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