SRSF2 protein (Homo sapiens) - STRING network view

STRING 9.05

SRSF2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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	SRSF2	splicing factor, arginine/serine-rich 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or [...] (221 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SRSF3	splicing factor, arginine/serine-rich 3; May be involved in RNA processing in relation with cel [...] (164 aa)		•	•	•	•	•	0.999
	U2AF1	U2 small nuclear RNA auxiliary factor 1; Plays a critical role in both constitutive and enhance [...] (240 aa)			•	•	•		0.999
	SRSF4	splicing factor, arginine/serine-rich 4; A probable role in alternative splice site selection d [...] (494 aa)			•	•	•		0.999
	SF3A2	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for 'A' comp [...] (464 aa)			•	•	•		0.995
	SRSF1	splicing factor, arginine/serine-rich 1; Plays a role in preventing exon skipping, ensuring the [...] (248 aa)		•	•	•	•		0.991
	TRA2B	transformer 2 beta homolog (Drosophila); Sequence-specific RNA-binding protein which participat [...] (288 aa)	•		•		•	•	0.979
	FUS	fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independe [...] (526 aa)			•	•	•		0.976
	U2AF2	U2 small nuclear RNA auxiliary factor 2; Necessary for the splicing of pre-mRNA. Binds to the p [...] (475 aa)				•	•		0.964
	SNRNP70	small nuclear ribonucleoprotein 70kDa (U1); Mediates the splicing of pre-mRNA by binding to the [...] (437 aa)			•	•	•	•	0.963
	SREK1	splicing factor, arginine/serine-rich 12; Participates in the regulation of alternative splicin [...] (624 aa)			•		•		0.963

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