NCK2 protein (Homo sapiens) - STRING interaction network

NCK2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	NCK2	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2); Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1 (380 aa)
		(Homo sapiens)
Predicted Functional Partners:
	EGFR	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB [...] (1210 aa)	•	•	•	0.999
	PDGFRB	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b anti [...] (1106 aa)	•	•	•	0.999
	LIMS1	LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new C [...] (387 aa)	•		•	0.998
	EFNB1	Ephrin-B1 precursor (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) (ELK ligand) (ELK- [...] (346 aa)	•	•	•	0.996
	IRS1	Insulin receptor substrate 1 (IRS-1); May mediate the control of various cellular processes by [...] (1242 aa)	•	•	•	0.994
	PTK2	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2); Non-rec [...] (1052 aa)	•	•	•	0.992
	PAK1	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) [...] (553 aa)	•	•		0.983
	WASL	Neural Wiskott-Aldrich syndrome protein (N-WASP); Regulates actin polymerization by stimulating [...] (505 aa)		•	•	0.974
	NPHS1	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor); Seems to play a role in t [...] (1243 aa)	•	•	•	0.974
	SOS1	Son of sevenless homolog 1 (SOS-1); Promotes the exchange of Ras-bound GDP by GTP (1333 aa)	•	•	•	0.973

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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