STRINGSTRING
syn7A syn7A vti1A vti1A vamp7A vamp7A syn8A syn8A syn8B syn8B snpA snpA nsfA nsfA Syn10 Syn10 vamp7B vamp7B DDB0185714 DDB0185714 DDB_G0269942 DDB_G0269942
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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syn7ASyntaxin-7A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion. May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Belongs to the syntaxin family. (356 aa)    
Predicted Functional Partners:
vti1A
Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Belongs to the VTI1 family.
   
 0.979
vamp7A
Vesicle-associated membrane protein 7A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis; Belongs to the synaptobrevin family.
   
 0.966
syn8A
Syntaxin-8A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion.
    
 0.963
syn8B
Probable syntaxin-8B.
    
 0.947
snpA
Alpha-soluble NSF attachment protein; May be required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in vesicle fusion with nsfA and probably SNARE proteins; Belongs to the SNAP family.
    
 0.930
nsfA
Vesicle-fusing ATPase; Required for vesicle-mediated transport. Involved in endocytosis and endosome-endosome fusion. May be required for transport from the endoplasmic reticulum to the Golgi stack, and for the fusion of transport vesicles within the Golgi cisternae. Required for cell polarity, locomotion and chemotaxis.
   
 0.925
Syn10
t-SNARE coiled-coil homology domain-containing protein.
    
 0.913
vamp7B
Vesicle-associated membrane protein 7B; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion (By similarity); Belongs to the synaptobrevin family.
   
 0.906
DDB0185714
Uncharacterized protein.
   
 0.896
DDB_G0269942
Uncharacterized protein; Belongs to the synaptobrevin family.
    
 0.887
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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