STRINGSTRING
syn8A syn8A vti1A vti1A syn7A syn7A vamp7A vamp7A snpA snpA syn5 syn5 vamp7B vamp7B DDB_G0269942 DDB_G0269942 Syn16A Syn16A Syn16B Syn16B Vti1B Vti1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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syn8ASyntaxin-8A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion. (152 aa)    
Predicted Functional Partners:
vti1A
Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Belongs to the VTI1 family.
   
 0.976
syn7A
Syntaxin-7A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for fusion of late endosomes with lysosomes and homotypic lysosomal fusion. May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Belongs to the syntaxin family.
    
 0.963
vamp7A
Vesicle-associated membrane protein 7A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis; Belongs to the synaptobrevin family.
    
 0.943
snpA
Alpha-soluble NSF attachment protein; May be required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in vesicle fusion with nsfA and probably SNARE proteins; Belongs to the SNAP family.
    
 0.895
syn5
t-SNARE family protein.
    
 0.888
vamp7B
Vesicle-associated membrane protein 7B; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion (By similarity); Belongs to the synaptobrevin family.
   
 0.884
DDB_G0269942
Uncharacterized protein; Belongs to the synaptobrevin family.
    
 0.869
Syn16A
t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.
    
 0.864
Syn16B
t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.
    
 0.864
Vti1B
Uncharacterized protein.
   
 0.821
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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