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comC comC tgrD1 tgrD1 tgrC1 tgrC1 alg9 alg9 dhkL dhkL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
comCEGF-like domain-containing protein comC; Regulates aggregation via a pathway that involves lagC and tgrD1/lagD. Inhibits lagC and activates lagD expression. (1501 aa)    
Predicted Functional Partners:
tgrD1
Tiger protein D1; May be involved in the regulation of aggregation. Activates tgrC1.
      
 0.852
tgrC1
Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1.
      
 0.780
alg9
Mannosyltransferase.
      
 0.449
dhkL
Hybrid signal transduction histidine kinase L; Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
      
 0.407
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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