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  LCK protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
LCK
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase); Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of [...] (539 aa)
(Homo sapiens)
Predicted Functional Partners:
CD4
T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3); Accessory protein [...] (458 aa)
     0.999
CD247
T-cell surface glycoprotein CD3 zeta chain precursor (T-cell receptor T3 zeta chain) (CD247 ant [...] (261 aa)
     0.999
PTPRC
Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45 antigen); Required for T-c [...] (1306 aa)
     0.999
LCP2
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyro [...] (533 aa)
     0.999
CD8A
T-cell surface glycoprotein CD8 alpha chain precursor (T-lymphocyte differentiation antigen T8/ [...] (235 aa)
     0.999
ZAP70
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyro [...] (628 aa)
    0.999
CD28
T-cell-specific surface glycoprotein CD28 precursor (TP44); Involved in T-cell activation, the [...] (234 aa)
     0.999
CBL
E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene [...] (906 aa)
     0.998
IL2RB
Interleukin-2 receptor subunit beta precursor (IL-2 receptor) (P70-75) (p75) (High affinity IL- [...] (551 aa)
     0.998
PTPN6
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C [...] (624 aa)
    0.998
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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