STRINGSTRING
XAF1 XAF1 XIAP XIAP PARP9 PARP9 IFI44 IFI44 IRF9 IRF9 CMPK2 CMPK2 ISG15 ISG15 PARP12 PARP12 USP18 USP18 IFIT3 IFIT3 IFIT1 IFIT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
XAF1XIAP-associated factor 1; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 fr [...] (327 aa)    
Predicted Functional Partners:
XIAP
RING-type domain-containing protein.
    
 
 0.964
PARP9
Poly(ADP-ribose) polymerase family member 9.
   
  
 0.784
IFI44
Interferon induced protein 44.
   
 
 0.752
IRF9
Interferon-stimulated transcription factor 3, gamma 48kDa.
   
 
 0.737
CMPK2
Cytidine/uridine monophosphate kinase 2.
   
 
 0.736
ISG15
Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated- killer (LAK) activi [...]
   
 
 0.731
PARP12
Uncharacterized protein.
   
  
 0.717
USP18
USP domain-containing protein; Belongs to the peptidase C19 family.
   
 
 0.701
IFIT3
Interferon-induced protein with tetratricopeptide repeats 3.
   
 
 0.687
IFIT1
Interferon induced protein with tetratricopeptide repeats 1.
   
 
 0.684
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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