ITK protein (Homo sapiens) - STRING interaction network

ITK protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	ITK	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT); Plays a role in T-cell proliferation and differentiation (620 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CD28	T-cell-specific surface glycoprotein CD28 precursor (TP44); Involved in T-cell activation, the [...] (234 aa)	•	•	•		0.999
	LCP2	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyro [...] (533 aa)	•	•	•		0.999
	PLCG1	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositi [...] (1412 aa)	•	•	•	•	0.990
	GRB2	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein A [...] (217 aa)	•	•	•	•	0.988
	FYN	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK); I [...] (537 aa)	•	•	•	•	0.984
	CD4	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3); Accessory protein [...] (458 aa)		•	•		0.983
	BLNK	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain prote [...] (456 aa)	•	•	•		0.982
	CBL	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene [...] (906 aa)	•	•	•		0.973
	VAV1	Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, [...] (845 aa)		•	•		0.972
	KHDRBS1	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-act [...] (443 aa)	•		•		0.969

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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