CHUK protein (Homo sapiens) - STRING interaction network

CHUK protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	CHUK	SPFH domain-containing protein 1 precursor (Protein KE04); Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phos [...] (745 aa)
		(Homo sapiens)
Predicted Functional Partners:
	IKBKG	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear fac [...] (487 aa)	•	•	•		0.999
	NFKBIA	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I [...] (317 aa)	•	•	•		0.999
	RELA	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit); NF-kappa-B is a pleiotropic t [...] (551 aa)	•	•	•		0.999
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) [...] (756 aa)	•	•	•	•	0.999
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinas [...] (946 aa)	•	•	•	•	0.999
	NFKB1	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains- Nuclear fa [...] (969 aa)	•	•	•		0.999
	NFKBIB	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thy [...] (356 aa)	•	•	•		0.999
	RELB	Transcription factor RelB (I-Rel); NF-kappa-B is a pleiotropic transcription factor which is pr [...] (579 aa)	•	•	•		0.997
	NFKB2	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocat [...] (930 aa)	•	•	•		0.997
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) [...] (455 aa)	•	•	•		0.997

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes		or: network depth

Server load: low (28%)

Link to this page