Lat protein (Rattus norvegicus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Lat	Linker for activation of T-cells family member 1 (36 kDa phospho- tyrosine adapter protein) (pp36) (p36-38); Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular cal [...] (241 aa)
		(Rattus norvegicus)
Predicted Functional Partners:
	Syk	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase); Positive effector of BCR-st [...] (629 aa)	•	•	0.969
	Grb2	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein A [...] (216 aa)	•	•	0.943
	Zap70	zeta-chain (TCR) associated protein kinase 70 (614 aa)	•	•	0.940
	Plcg1	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositi [...] (1292 aa)	•	•	0.926
	ENSRNOG00000018316	GRB2-related adaptor protein 2 (324 aa)	•	•	0.902
	Plcg2	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositi [...] (1107 aa)	•	•	0.880
	Lyn	Tyrosine-protein kinase Lyn (EC 2.7.10.2) (512 aa)		•	0.870
	Lcp2	lymphocyte cytosolic protein 2 (531 aa)		•	0.834
	Ngf	Beta-nerve growth factor precursor (Beta-NGF); Nerve growth factor is important for the develop [...] (303 aa)		•	0.832
	Ptpn11	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase S [...] (597 aa)	•	•	0.809

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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