LRRK2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa)
(Homo sapiens)
Predicted Functional Partners:
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes [...] (854 aa)
moesin; Probably involved in connections of major cytoskeletal structures to the plasma membran [...] (577 aa)
eukaryotic translation initiation factor 4E binding protein 1; Regulates eIF4E activity by prev [...] (118 aa)
myelin basic protein (197 aa)
cell division cycle 37 homolog (S. cerevisiae); Co-chaperone that binds to numerous kinases and [...] (378 aa)
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)
microtubule-associated protein 1B; Facilitates tyrosination of alpha-tubulin in neuronal microt [...] (2468 aa)
ADP-ribosylation factor GTPase activating protein 1 (414 aa)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (245 aa)
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the tra [...] (646 aa)
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