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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
VTCN1
V-set domain containing T cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation (285 aa)
(Homo sapiens)
Predicted Functional Partners:
BTLA
B- and T-lymphocyte attenuator precursor (B- and T-lymphocyte- associated protein) (CD272 antig [...] (289 aa)
    • • 0.975
CTLA4
Cytotoxic T-lymphocyte protein 4 precursor (Cytotoxic T-lymphocyte- associated antigen 4) (CTLA [...] (223 aa)
      • 0.917
ICOS
Inducible T-cell co-stimulator precursor (Activation-inducible lymphocyte immunomediatory molec [...] (199 aa)
      • 0.891
CD28
T-cell-specific surface glycoprotein CD28 precursor (TP44); Involved in T-cell activation, the [...] (234 aa)
      • 0.865
CD80
T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-recept [...] (288 aa)
      • 0.828
TNFRSF14
Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) ( [...] (283 aa)
      • 0.820
PDCD1
Programmed cell death protein 1 precursor (Protein PD-1) (hPD-1) (CD279 antigen); Possible cell [...] (288 aa)
      • 0.702
IL2
Interleukin-2 precursor (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin); Produced by T-cells [...] (153 aa)
      • 0.697
SPON2
Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cell [...] (331 aa)
      • 0.663
PTPN11
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2 [...] (593 aa)
      • 0.636
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth