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  MAP3K8 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
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MAP3K8
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene); Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein (467 aa)
(Homo sapiens)
Predicted Functional Partners:
TNIP2
A20-binding inhibitor of NF-kappaB activation 2; Inhibits NF-kappa-B activation by blocking the [...] (429 aa)
      0.990
MAP3K14
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinas [...] (946 aa)
    0.985
NFKB1
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains- Nuclear fa [...] (969 aa)
      0.982
NEDD9
Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p [...] (834 aa)
       0.978
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) [...] (393 aa)
   0.975
MAP2K4
Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) [...] (399 aa)
    0.973
AKT1
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) [...] (480 aa)
    0.966
CHUK
SPFH domain-containing protein 1 precursor (Protein KE04); Acts as part of the IKK complex in t [...] (745 aa)
    0.944
MAP2K5
Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) [...] (474 aa)
     0.904
KRR1
KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (Rev-interacting [...] (381 aa)
       0.904
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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