PTPRC protein (Homo sapiens) - STRING interaction network

PTPRC protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PTPRC	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) (CD45 antigen); Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN (1306 aa)
		(Homo sapiens)
Predicted Functional Partners:
	LCK	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific pr [...] (539 aa)	•	•	•	0.999
	CD4	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3); Accessory protein [...] (458 aa)	•	•	•	0.999
	LYN	Tyrosine-protein kinase Lyn (EC 2.7.10.2) (582 aa)	•	•	•	0.999
	CD22	B-cell receptor CD22 precursor (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (Leu-14) (B-ly [...] (847 aa)	•	•	•	0.998
	CD247	T-cell surface glycoprotein CD3 zeta chain precursor (T-cell receptor T3 zeta chain) (CD247 ant [...] (261 aa)	•	•	•	0.998
	FYN	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK); I [...] (537 aa)	•	•	•	0.997
	CD79A	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membr [...] (226 aa)	•	•	•	0.994
	CXCR4	C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell- derived factor 1 receptor) (SD [...] (356 aa)	•	•	•	0.991
	SEMA4D	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3); May play a func [...] (862 aa)	•	•	•	0.991
	ITGAM	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) ( [...] (1143 aa)			•	0.986

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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