Ptprc protein (Mus musculus) - STRING interaction network

Ptprc protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	Ptprc	protein tyrosine phosphatase, receptor type, C; Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN (1340 aa)
		(Mus musculus)
Predicted Functional Partners:
	Cd4	CD4 antigen; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regula [...] (457 aa)	•	•	•	0.999
	Lck	lymphocyte protein tyrosine kinase; Tyrosine kinase that plays an essential role for the select [...] (509 aa)	•	•	•	0.997
	Cd22	CD22 antigen; Mediates B-cell B-cell interactions. May be involved in the localization of B-cel [...] (868 aa)	•	•	•	0.993
	Fyn	Fyn proto-oncogene; Implicated in the control of cell growth. Plays a role in the regulation of [...] (537 aa)		•	•	0.987
	Cd247	CD247 antigen; Probable role in assembly and expression of the TCR complex as well as signal tr [...] (206 aa)	•	•	•	0.987
	Cd3e	CD3 antigen, epsilon polypeptide; The CD3 complex mediates signal transduction (189 aa)		•	•	0.980
	Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog (491 aa)	•	•	•	0.971
	Itgal	integrin alpha L; Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is i [...] (1162 aa)	•		•	0.958
	Il2ra	interleukin 2 receptor, alpha chain; Receptor for interleukin-2 (268 aa)			•	0.954
	Cd3d	CD3 antigen, delta polypeptide; The CD3 complex mediates signal transduction (173 aa)		•	•	0.945

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