MAP3K14 protein (Homo sapiens) - STRING interaction network

MAP3K14 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK); Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner (By similarity) (946 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CHUK	SPFH domain-containing protein 1 precursor (Protein KE04); Acts as part of the IKK complex in t [...] (745 aa)	•	•	•	•	0.999
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) [...] (756 aa)	•	•	•	•	0.999
	TRAF2	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3); [...] (553 aa)	•	•	•		0.992
	NFKB2	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocat [...] (930 aa)	•	•	•		0.992
	IKBKG	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear fac [...] (487 aa)	•	•	•		0.990
	TRAF6	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85); Ad [...] (524 aa)	•		•		0.989
	TRAF3	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding prot [...] (568 aa)	•	•	•		0.988
	MAP3K8	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/thre [...] (467 aa)	•	•	•	•	0.985
	TRAF1	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6); Adapter protein and si [...] (416 aa)	•	•			0.982
	RELB	Transcription factor RelB (I-Rel); NF-kappa-B is a pleiotropic transcription factor which is pr [...] (579 aa)		•	•		0.980

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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