GSK3B protein (Homo sapiens) - STRING interaction network

GSK3B protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	GSK3B	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta); Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin (433 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CTNNB1	Catenin beta-1 (Beta-catenin); Involved in the regulation of cell adhesion and in signal transd [...] (781 aa)	•	•	•		0.999
	AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin); Controls dorsoventral patterning via two opposing e [...] (911 aa)	•	•	•		0.999
	MAPT	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-ta [...] (776 aa)	•	•	•		0.999
	FRAT1	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1); Positively [...] (279 aa)	•	•	•		0.999
	TP53	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13); Acts [...] (393 aa)	•	•	•		0.999
	LRP6	Low-density lipoprotein receptor-related protein 6 precursor; Essential for the Wnt/beta cateni [...] (1613 aa)	•	•	•		0.998
	AKT1	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) [...] (480 aa)	•	•	•	•	0.998
	TSC2	Tuberin (Tuberous sclerosis 2 protein); Implicated as a tumor suppressor. May have a function i [...] (1807 aa)	•	•	•		0.997
	CCND1	G1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene); Essential for the control of the cel [...] (295 aa)	•	•	•		0.997
	FRAT2	GSK-3-binding protein FRAT2 (Frat-2); Positively regulates the Wnt signaling pathway by stabili [...] (233 aa)	•	•	•		0.997

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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