PPP2CA protein (Homo sapiens) - STRING interaction network

PPP2CA protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	PPP2CA	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (EC 3.1.3.16) (PP2A-alpha) (Replication protein C) (RP-C); PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser e [...] (309 aa)
		(Homo sapiens)
Predicted Functional Partners:
	PPP2R1A	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subuni [...] (589 aa)	•	•	•	0.999
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subuni [...] (540 aa)	•	•	•	0.999
	PPP2R4	Serine/threonine-protein phosphatase 2A regulatory subunit B' (PP2A, subunit B', PR53 isoform) [...] (358 aa)	•	•	•	0.999
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit [...] (667 aa)	•	•	•	0.998
	AKT1	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) [...] (480 aa)	•	•	•	0.998
	DOCK5	Dedicator of cytokinesis protein 5; The B regulatory subunit might modulate substrate selectivi [...] (1870 aa)	•	•	•	0.995
	SGOL1	Shugoshin-like 1 (hSgo1) (Serologically defined breast cancer antigen NY-BR-85); Plays a centra [...] (561 aa)	•	•	•	0.987
	IGBP1	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule [...] (339 aa)	•		•	0.987
	PPP2R2C	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PP2A, subuni [...] (447 aa)	•	•	•	0.987
	PPP2R3B	Serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B (PP2A, subunit B, PR48 isof [...] (575 aa)	•	•	•	0.985

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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