A2m protein (Rattus norvegicus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	A2m	Alpha-2-macroglobulin precursor (Alpha-2-M); Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyz [...] (1472 aa)
		(Rattus norvegicus)
Predicted Functional Partners:
	Lrp1	Lrp1 protein (Fragment) (4545 aa)		•	•		0.953
	Il6	Interleukin-6 precursor (IL-6); IL-6 is a cytokine with a wide variety of biological functions- [...] (210 aa)			•		0.946
	Ptpra	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phos [...] (830 aa)			•		0.945
	LOC25087	T-kininogen 2 precursor (T-kininogen II) (Major acute phase protein) (Alpha-1-MAP) (Thiostatin) [...] (532 aa)		•	•		0.920
	Klkb1	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher facto [...] (638 aa)		•	•		0.914
	A1m	Alpha-1-macroglobulin precursor (Alpha-1-M) [Contains- Alpha-1- macroglobulin 165 kDa subunit; [...] (1500 aa)		•	•	•	0.904
	A1i3	Alpha-1-inhibitor 3 precursor (Alpha-1-inhibitor III) (Alpha-1- inhibitor 3 variant II); A prot [...] (1476 aa)		•	•	•	0.903
	ENSRNOG00000025332	annotation not available (1122 aa)	•	•		•	0.903
	Mug1	Murinoglobulin-1 precursor (Alpha-1 inhibitor 3 variant I) (Alpha-X protein); A proteinase acti [...] (1487 aa)		•	•	•	0.903
	Srgap2	Putative uncharacterized protein (985 aa)		•			0.899

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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