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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
Pdx1
pancreatic and duodenal homeobox 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'- CC[CT]TAATGGG-3' (284 aa)
(Mus musculus)
Predicted Functional Partners:
Nr5a2
nuclear receptor subfamily 5, group A, member 2; Binds to promoters containing the sequence ele [...] (560 aa)
      0.980
Foxa2
forkhead box A2; Transcription activator for a number of liver genes such as AFP, albumin, tyro [...] (459 aa)
       0.980
Gck
glucokinase; Catalyzes the initial step in utilization of glucose by the beta-cell and liver at [...] (465 aa)
      0.978
Iapp
islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glyc [...] (93 aa)
      0.977
Ins1
insulin I; Insulin decreases blood glucose concentration. It increases cell permeability to mon [...] (108 aa)
      0.977
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2; Facilitative glucose trans [...] (525 aa)
       0.976
Gcg
glucagon; Glicentin may modulate gastric acid secretion and gastro-pyloro-duodenal activity (180 aa)
       0.964
ENSMUSG00000043013
one cut domain, family member 1; Transcriptional activator. Binds the consensus sequence 5'-DHW [...] (465 aa)
      0.959
Hipk2
homeodomain interacting protein kinase 2; Protein kinase acting as a corepressor of several tra [...] (1196 aa)
       0.956
Neurod1
neurogenic differentiation 1; Differentiation factor required for dendrite morphogenesis and ma [...] (357 aa)
       0.955
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
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additional (white) nodes         or: network depth