USP7 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	USP7	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease); Cleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53- dependent cell growth repression and apoptosis (1110 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TP53	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13); Acts [...] (393 aa)	•		•	0.999
	MDM2	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Do [...] (491 aa)	•		•	0.995
	MDM4	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double [...] (490 aa)	•		•	0.973
	MLLT7	Fork head domain transcription factor AFX1 (Forkhead box protein O4); Transcription factor invo [...] (505 aa)		•	•	0.960
	ENSG00000150991	Ubiquitin; Protein modifier which can be covalently attached to target lysines either as a mono [...] (685 aa)	•		•	0.934
	GMPS	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase) [...] (693 aa)	•		•	0.920
	DAXX	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-a [...] (740 aa)	•		•	0.859
	TRAF6	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85); Ad [...] (524 aa)	•		•	0.786
	CLSPN	Claspin (hClaspin) (Hu-Claspin); Required for checkpoint mediated cell cycle arrest in response [...] (1341 aa)	•		•	0.783
	TEAD1	Transcriptional enhancer factor TEF-1 (TEA domain family member 1) (TEAD-1) (Protein GT-IIC) (T [...] (426 aa)	•		•	0.751

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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