node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPD2 | APRT | ENSCAFP00000031117 | ENSCAFP00000029425 | Adenosine monophosphate deaminase 2. | Adenine phosphoribosyltransferase. | 0.986 |
AMPD2 | ATIC | ENSCAFP00000031117 | ENSCAFP00000021114 | Adenosine monophosphate deaminase 2. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.917 |
AMPD2 | GMPR | ENSCAFP00000031117 | ENSCAFP00000014617 | Adenosine monophosphate deaminase 2. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.937 |
AMPD2 | GMPR2 | ENSCAFP00000031117 | ENSCAFP00000017919 | Adenosine monophosphate deaminase 2. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.937 |
AMPD2 | HPRT1 | ENSCAFP00000031117 | ENSCAFP00000037274 | Adenosine monophosphate deaminase 2. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.938 |
AMPD2 | IMPDH1 | ENSCAFP00000031117 | ENSCAFP00000002420 | Adenosine monophosphate deaminase 2. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.953 |
AMPD2 | PNP | ENSCAFP00000031117 | ENSCAFP00000008083 | Adenosine monophosphate deaminase 2. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.705 |
APRT | AMPD2 | ENSCAFP00000029425 | ENSCAFP00000031117 | Adenine phosphoribosyltransferase. | Adenosine monophosphate deaminase 2. | 0.986 |
APRT | ATIC | ENSCAFP00000029425 | ENSCAFP00000021114 | Adenine phosphoribosyltransferase. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.963 |
APRT | GDA | ENSCAFP00000029425 | ENSCAFP00000002645 | Adenine phosphoribosyltransferase. | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. | 0.941 |
APRT | GMPR | ENSCAFP00000029425 | ENSCAFP00000014617 | Adenine phosphoribosyltransferase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.954 |
APRT | GMPR2 | ENSCAFP00000029425 | ENSCAFP00000017919 | Adenine phosphoribosyltransferase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.955 |
APRT | GMPS | ENSCAFP00000029425 | ENSCAFP00000036506 | Adenine phosphoribosyltransferase. | Uncharacterized protein. | 0.986 |
APRT | HPRT1 | ENSCAFP00000029425 | ENSCAFP00000037274 | Adenine phosphoribosyltransferase. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.969 |
APRT | IMPDH1 | ENSCAFP00000029425 | ENSCAFP00000002420 | Adenine phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. | 0.632 |
APRT | PNP | ENSCAFP00000029425 | ENSCAFP00000008083 | Adenine phosphoribosyltransferase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.990 |
ATIC | AMPD2 | ENSCAFP00000021114 | ENSCAFP00000031117 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Adenosine monophosphate deaminase 2. | 0.917 |
ATIC | APRT | ENSCAFP00000021114 | ENSCAFP00000029425 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Adenine phosphoribosyltransferase. | 0.963 |
ATIC | GMPR | ENSCAFP00000021114 | ENSCAFP00000014617 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.964 |
ATIC | GMPR2 | ENSCAFP00000021114 | ENSCAFP00000017919 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.965 |