DOT1 protein (Eremothecium gossypii) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	DOT1	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity) (575 aa)
		(Eremothecium gossypii)
Predicted Functional Partners:
	SET2	Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that methy [...] (684 aa)	•	•	0.756
	SET1	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (S [...] (975 aa)	•	•	0.740
	ACL099W	ACL099Wp (357 aa)	•	•	0.641
	RAD18	Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the [...] (443 aa)	•	•	0.615
	AAR136W	AAR136Wp (617 aa)	•	•	0.583
	RAD17	DNA damage checkpoint control protein RAD17; Exonuclease component of the checkpoint clamp comp [...] (389 aa)	•		0.562
	ACR041W	ACR041Wp (326 aa)	•		0.557
	ADL028W	ADL028Wp (577 aa)	•		0.555
	AEL258W	AEL258Wp (526 aa)		•	0.553
	RAD5	DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions [...] (1085 aa)	•	•	0.543

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes		or: network depth