Itk protein (Mus musculus) - STRING interaction network

Itk protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Itk	IL2-inducible T-cell kinase; May play a role in T-cell development, potentially in thymic selection (625 aa)
		(Mus musculus)
Predicted Functional Partners:
	Cd4	CD4 antigen; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regula [...] (457 aa)		•	•		0.972
	Lcp2	lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling (533 aa)	•	•	•		0.972
	Il2	interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this prot [...] (169 aa)			•		0.956
	Tbx21	T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gam [...] (530 aa)	•		•		0.954
	Vav1	vav 1 oncogene; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thu [...] (845 aa)		•	•		0.943
	Lat	linker for activation of T cells; Required for TCR (T-cell antigen receptor)- and pre-TCR- medi [...] (242 aa)			•		0.926
	Cd3e	CD3 antigen, epsilon polypeptide; The CD3 complex mediates signal transduction (189 aa)		•	•		0.922
	Zap70	zeta-chain (TCR) associated protein kinase; Plays a role in T-cell development and lymphocyte a [...] (618 aa)		•	•	•	0.921
	Cd247	CD247 antigen; Probable role in assembly and expression of the TCR complex as well as signal tr [...] (206 aa)		•	•		0.918
	Syk	spleen tyrosine kinase; Positive effector of BCR-stimulated responses. Couples the B-cell antig [...] (629 aa)		•	•	•	0.915

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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