node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atu0988 | clpA | Atu0988 | Atu1364 | Molecular chaperone, Hsp70 family. | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.866 |
Atu0988 | clpB | Atu0988 | Atu4177 | Molecular chaperone, Hsp70 family. | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | 0.866 |
Atu0988 | clpB-2 | Atu0988 | Atu4344 | Molecular chaperone, Hsp70 family. | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.866 |
Atu0988 | dnaJ | Atu0988 | Atu0121 | Molecular chaperone, Hsp70 family. | Molecular chaperone, DnaJ family; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.899 |
Atu0988 | dnaJ-2 | Atu0988 | Atu0758 | Molecular chaperone, Hsp70 family. | Molecular chaperone, DnaJ family. | 0.899 |
Atu0988 | dnaJ-3 | Atu0988 | Atu2006 | Molecular chaperone, Hsp70 family. | Molecular chaperone, DnaJ family. | 0.892 |
Atu0988 | dnaJ-4 | Atu0988 | Atu3623 | Molecular chaperone, Hsp70 family. | Molecular chaperone, DnaJ family. | 0.902 |
Atu0988 | groEL | Atu0988 | Atu0682 | Molecular chaperone, Hsp70 family. | GroEL chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.908 |
Atu0988 | groES | Atu0988 | Atu0683 | Molecular chaperone, Hsp70 family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.855 |
Atu0988 | grpE | Atu0988 | Atu0329 | Molecular chaperone, Hsp70 family. | GRPE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.944 |
clpA | Atu0988 | Atu1364 | Atu0988 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, Hsp70 family. | 0.866 |
clpA | dnaJ | Atu1364 | Atu0121 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, DnaJ family; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.667 |
clpA | dnaJ-2 | Atu1364 | Atu0758 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, DnaJ family. | 0.631 |
clpA | dnaJ-3 | Atu1364 | Atu2006 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, DnaJ family. | 0.603 |
clpA | dnaJ-4 | Atu1364 | Atu3623 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, DnaJ family. | 0.592 |
clpA | groEL | Atu1364 | Atu0682 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GroEL chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.664 |
clpA | groES | Atu1364 | Atu0683 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.631 |
clpA | grpE | Atu1364 | Atu0329 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GRPE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.742 |
clpB | Atu0988 | Atu4177 | Atu0988 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | Molecular chaperone, Hsp70 family. | 0.866 |
clpB | dnaJ | Atu4177 | Atu0121 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | Molecular chaperone, DnaJ family; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.621 |