Axin1 protein (Mus musculus) - STRING interaction network

Axin1 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Axin1	axin 1; Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of beta- catenin and APC by GSK3B. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (863 aa)
		(Mus musculus)
Predicted Functional Partners:
	Ctnnb1	catenin (cadherin associated protein), beta 1; Involved in the regulation of cell adhesion and [...] (781 aa)	•	•	•	0.999
	Gsk3b	glycogen synthase kinase 3 beta; Participates in the Wnt signaling pathway. Implicated in the h [...] (420 aa)	•	•	•	0.999
	Csnk1e	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utiliz [...] (416 aa)	•	•	•	0.992
	Csnk1a1	casein kinase 1, alpha 1; Casein kinases are operationally defined by their preferential utiliz [...] (337 aa)	•	•	•	0.989
	Lrp6	low density lipoprotein receptor-related protein 6; Essential for the Wnt/beta catenin signalin [...] (1595 aa)	•	•	•	0.986
	Apc	adenomatosis polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and partici [...] (2842 aa)	•	•	•	0.970
	Lrp5	low density lipoprotein receptor-related protein 5; Involved in the Wnt/beta catenin signaling [...] (1614 aa)	•	•	•	0.969
	Jup	junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are ar [...] (745 aa)	•	•	•	0.957
	Btrc	beta-transducin repeat containing protein (605 aa)	•	•	•	0.950
	Wnt3a	wingless-related MMTV integration site 3A; Ligand for members of the frizzled family of seven t [...] (352 aa)			•	0.944

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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