STRINGSTRING
Crybg3 Crybg3 Arl6 Arl6 Cuedc2 Cuedc2 Cryzl1 Cryzl1 Zfp654 Zfp654 Ldha Ldha Pom121l12 Pom121l12 Cryl1 Cryl1 Lgsn Lgsn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Crybg3Beta/gamma crystallin domain-containing protein 3. (2952 aa)    
Predicted Functional Partners:
Arl6
ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity). Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity). May regulate cilia assembl [...]
 
  
 
 0.591
Cuedc2
CUE domain-containing protein 2; Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Belongs to the CUEDC2 family.
      
 0.591
Cryzl1
Quinone oxidoreductase-like protein 1.
      
 0.588
Zfp654
Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
 
 0.588
Ldha
L-lactate dehydrogenase A chain; Belongs to the LDH/MDH superfamily. LDH family.
      
 0.567
Pom121l12
POM121 membrane glycoprotein-like 12.
      
 0.538
Cryl1
Lambda-crystallin homolog; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
      
 0.445
Lgsn
Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.
      
 0.428
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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