STRINGSTRING
GKN2 GKN2 TFF1 TFF1 TFF2 TFF2 GKN1 GKN1 PGC PGC LIPF LIPF MUCL3 MUCL3 CBLIF CBLIF CLDN18 CLDN18 C16orf91 C16orf91 TFF3 TFF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GKN2Gastrokine-2; Gastrokine 2. (184 aa)    
Predicted Functional Partners:
TFF1
Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.
   
  
 0.879
TFF2
Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).
   
  
 0.785
GKN1
Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
  
  
0.731
PGC
Gastricsin; Hydrolyzes a variety of proteins; Belongs to the peptidase A1 family.
   
  
 0.569
LIPF
Lipase F, gastric type.
   
  
 0.551
MUCL3
Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth.
   
  
 0.540
CBLIF
Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis; Belongs to the eukaryotic cobalamin transport proteins family.
   
  
 0.528
CLDN18
Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.514
C16orf91
Protein CCSMST1; Chromosome 16 open reading frame 91.
      
 0.508
TFF3
Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
   
  
 0.490
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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