Clock protein (Mus musculus) - STRING interaction network

Clock protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Clock	circadian locomoter output cycles kaput; ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4. Acetylates also a non-histone substrate- its own partner, ARNTL (857 aa)
		(Mus musculus)
Predicted Functional Partners:
	Cry1	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop [...] (606 aa)	•	•	•		0.999
	Arntl	aryl hydrocarbon receptor nuclear translocator-like; ARNTL-CLOCK heterodimers activate E-box el [...] (627 aa)	•	•	•	•	0.999
	Cry2	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop [...] (592 aa)	•		•		0.999
	Per1	period homolog 1 (Drosophila); Component of the circadian clock mechanism which is essential fo [...] (1291 aa)	•	•	•	•	0.999
	Per3	period homolog 3 (Drosophila); Component of the circadian clock mechanism which is essential fo [...] (1113 aa)	•	•	•	•	0.999
	Per2	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential fo [...] (1257 aa)	•	•	•	•	0.999
	Bhlhb3	basic helix-loop-helix domain containing, class B3; May be a transcriptional repressor that rep [...] (410 aa)			•		0.989
	Bhlhb2	basic helix-loop-helix domain containing, class B2; May function as a transcriptional factor fo [...] (411 aa)			•		0.989
	Sirt1	sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae); NAD-depend [...] (737 aa)	•		•		0.986
	Nr1d1	nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional re [...] (615 aa)		•	•		0.961

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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