Orai1 protein (Mus musculus) - STRING network view

STRING 9.05

Orai1 protein (Mus musculus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Orai1	ORAI calcium release-activated calcium modulator 1 Gene; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (By similarity) (304 aa)
		(Mus musculus)
Predicted Functional Partners:
	Stim1	stromal interaction molecule 1 Gene; Plays a role in mediating Ca(2+) influx following depletio [...] (685 aa)	•	•	•	0.995
	Itpr1	inositol 1,4,5-triphosphate receptor 1 Gene; Intracellular channel that mediates calcium releas [...] (2749 aa)		•	•	0.911
	Itpr3	inositol 1,4,5-triphosphate receptor 3 Gene; Receptor for inositol 1,4,5-trisphosphate, a secon [...] (2670 aa)		•	•	0.909
	Itpr2	inositol 1,4,5-triphosphate receptor 2 Gene; Receptor for inositol 1,4,5-trisphosphate, a secon [...] (2701 aa)		•		0.899
	Calm1	calmodulin 1 Gene; Calmodulin mediates the control of a large number of enzymes and other prote [...] (197 aa)			•	0.829
	Stim2	stromal interaction molecule 2 Gene; Functions as a highly sensitive Ca(2+) sensor in the endop [...] (820 aa)			•	0.643
	Efcab4a	EF-hand calcium binding domain 4A Gene (394 aa)			•	0.591
	ENSMUSG00000076470	T-cell receptor beta chain V region C5 Precursor; Fragment (113 aa)			•	0.560
	Trpc1	transient receptor potential cation channel, subfamily C, member 1 Gene; Thought to form a rece [...] (809 aa)			•	0.554
	Trpc3	transient receptor potential cation channel, subfamily C, member 3 Gene; Thought to form a rece [...] (910 aa)			•	0.400

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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