STRINGSTRING
Gramd4 Gramd4 Ccnj Ccnj Gnl1 Gnl1 Rnf130 Rnf130 Rtn4 Rtn4 Ttpal Ttpal Gapdhs Gapdhs Fam186a Fam186a Nkrf Nkrf Btbd9 Btbd9 Spata4 Spata4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gramd4GRAM domain-containing protein 4; Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (By similarity). Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response. (633 aa)    
Predicted Functional Partners:
Ccnj
Cyclin-J.
   
  
 0.602
Gnl1
Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.
   
  
 0.542
Rnf130
E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells.
   
  
 0.467
Rtn4
Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remod [...]
      
 0.457
Ttpal
Alpha-tocopherol transfer protein-like; May act as a protein that binds a hydrophobic ligand.
   
  
 0.447
Gapdhs
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility.
      
 0.444
Fam186a
Protein FAM186A.
    
 
 0.429
Nkrf
NF-kappa-B-repressing factor; Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK- kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription (By similarity).
   
 
 0.429
Btbd9
BTB/POZ domain-containing protein 9.
   
 
 0.425
Spata4
Spermatogenesis-associated protein 4; May play a role in apoptosis regulation.
    
 
 0.403
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (30%) [HD]