Socs2 protein (Mus musculus) - STRING interaction network

Socs2 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Socs2	suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (198 aa)
		(Mus musculus)
Predicted Functional Partners:
	Lepr	leptin receptor; Isoform E could function as a transport protein (1162 aa)	•	•	•		0.949
	Ghr	growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating pos [...] (650 aa)	•	•	•		0.934
	Prlr	prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin (608 aa)	•	•	•		0.914
	Jak2	Janus kinase 2; Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probabl [...] (1132 aa)		•	•		0.907
	Tceb2	transcription elongation factor B (SIII), polypeptide 2; SIII, also known as elongin, is a gene [...] (117 aa)	•		•		0.903
	Il10ra	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (575 aa)		•	•		0.872
	Jak1	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma [...] (1156 aa)		•	•		0.868
	Irs4	insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors pos [...] (1216 aa)		•	•		0.862
	Epor	erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythrob [...] (507 aa)	•	•	•		0.858
	Socs3	suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)	•	•	•	•	0.858

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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