node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEBP1 | BGN | ENSP00000223357 | ENSP00000327336 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Biglycan; May be involved in collagen fiber assembly. | 0.566 |
AEBP1 | COL14A1 | ENSP00000223357 | ENSP00000297848 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | 0.543 |
AEBP1 | COL1A1 | ENSP00000223357 | ENSP00000225964 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.562 |
AEBP1 | COL1A2 | ENSP00000223357 | ENSP00000297268 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.578 |
AEBP1 | COL5A1 | ENSP00000223357 | ENSP00000360882 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. | 0.576 |
AEBP1 | COL5A2 | ENSP00000223357 | ENSP00000364000 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | 0.561 |
AEBP1 | COL6A2 | ENSP00000223357 | ENSP00000300527 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | 0.572 |
AEBP1 | FMOD | ENSP00000223357 | ENSP00000347041 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.549 |
AEBP1 | TCF3 | ENSP00000223357 | ENSP00000262965 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B- cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. | 0.650 |
AEBP1 | THBS2 | ENSP00000223357 | ENSP00000355751 | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties. | 0.595 |
BGN | AEBP1 | ENSP00000327336 | ENSP00000223357 | Biglycan; May be involved in collagen fiber assembly. | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | 0.566 |
BGN | COL14A1 | ENSP00000327336 | ENSP00000297848 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | 0.514 |
BGN | COL1A1 | ENSP00000327336 | ENSP00000225964 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.974 |
BGN | COL1A2 | ENSP00000327336 | ENSP00000297268 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.938 |
BGN | COL5A1 | ENSP00000327336 | ENSP00000360882 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. | 0.774 |
BGN | COL5A2 | ENSP00000327336 | ENSP00000364000 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | 0.807 |
BGN | COL6A2 | ENSP00000327336 | ENSP00000300527 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein. | 0.816 |
BGN | FMOD | ENSP00000327336 | ENSP00000347041 | Biglycan; May be involved in collagen fiber assembly. | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.976 |
BGN | THBS2 | ENSP00000327336 | ENSP00000355751 | Biglycan; May be involved in collagen fiber assembly. | Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties. | 0.693 |
COL14A1 | AEBP1 | ENSP00000297848 | ENSP00000223357 | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). | Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family. | 0.543 |