Pak4 protein (Mus musculus) - STRING interaction network

Pak4 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Pak4	p21 (CDKN1A)-activated kinase 4; Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity) (593 aa)
		(Mus musculus)
Predicted Functional Partners:
	Arhgef7	Rho guanine nucleotide exchange factor (GEF7); Acts as a RAC1 guanine nucleotide exchange facto [...] (741 aa)			•	•		0.966
	Cdc42	cell division cycle 42 homolog (S. cerevisiae); Plasma membrane-associated small GTPase which c [...] (191 aa)			•	•		0.955
	Mylk2	myosin, light polypeptide kinase 2, skeletal muscle; Implicated in the level of global muscle c [...] (240 aa)		•	•	•	•	0.831
	Pak3	p21 (CDKN1A)-activated kinase 3; Key regulator of synapse formation and plasticity in the hippo [...] (559 aa)		•	•	•	•	0.829
	Arhgef6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchang [...] (770 aa)			•	•		0.829
	Pak2	p21 (CDKN1A)-activated kinase 2; The activated kinase acts on a variety of targets. Full length [...] (524 aa)		•	•	•	•	0.825
	Pak7	p21 (CDKN1A)-activated kinase 7; The activated kinase acts on a variety of targets (By similari [...] (719 aa)	•		•	•	•	0.821
	Pak1	p21 (CDKN1A)-activated kinase 1; The activated kinase acts on a variety of targets. Likely to b [...] (544 aa)		•	•		•	0.816
	Map2k1	mitogen activated protein kinase kinase 1; Catalyzes the concomitant phosphorylation of a threo [...] (393 aa)		•	•		•	0.816
	Pak1ip1	PAK1 interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK k [...] (382 aa)				•		0.816

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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